Relationship between vitamin D sufficiency and interferon-γ levels in children with chronic lung diseases

Introduction . The role and mechanism of the effect vitamin D on course chronic lung diseases in children are not yet fully understood. In particular, there enough studies status production interferon-γ (IFN-γ) with cystic fibrosis bronchial asthma. Aim To analyse changes IFN-γ levels asthma according to serum 25(OH)D level before during cholecalciferol supplementation. Materials methods A total 114 (aged from 3 months 18 years old) were examined, including 51 (44.7%) asthma, 34 (29.8%) fibrosis, 29 (25.5%) control group. If hypovitaminosis was diagnosed, received a three-month at doses accordance recommendations national consensus - Cystic Fibrosis: Definition, Diagnostic Criteria, Therapy program Vitamin Deficiency Children Adolescents Russian Federation: Current Approaches Management. twice determined all children. Results Median patients did reach healthy either or after supplementation drugs recommended doses. intake resulted decrease 3.07 [2.29; 4.81] pg/ml 2.18 [1.74; 3.45] (p < 0.05), whereas such detected paediatric general population. However, cholecalciferol, significantly higher 2.86 [2.13; 3.86] 3.11 [0.89; 5.0] pg/ml, respectively, than 0.05). statistically significant observed girls no groups boys. Conclusion Modulation appears be one mechanisms immunotropic inflammation infectious (cystic fibrosis) allergic (bronchial asthma) etiology